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Dr. Vahab Ali
Scientist D
 
   
Date of Birth:
01-10-1969
Sex: Male
Date of Joining in ICMR: 28th March 2008
Designation: Scientist D
Discipline: Biochemistry
Date of Joining in Present Post:
2 nd June 2011
Office

Department of Biochemistry
Rajendra Memorial Research Institute of Medical Sciences
(Indian Council of Medical Research)Department of Health Research, Ministry of Health & Family Welfare, Govt of India, Agamkuan, Patna-800007
Telephone: 0612- 2631565
Fax: 0612-2634379
Residence: Flat No. 205, B Block
Chunni Ka Plaza, Kankarbag Main Road
(Near Nalanda Medical College) Patna-26.
Telephone: +91-9304184301/9304836301
E-Mail: vahab_ali@yahoo.com
 
Educational Qualifications:
  1. Dec. 1997 - Ph. D. Biochemistry, Division of Structural and Molecular Biology, Central Drug Research Institute, Lucknow, India (Degree awarded from Aligarh Muslim University, Aligarh, India)

  2. Dec. 1993 - M. Phil. Biochemistry, Division of Structural and Molecular Biology, Central Drug Research Institute, Lucknow, India (Degree awarded from Aligarh Muslim University, Aligarh, India)

  3. July 1990 - M. Sc. Biochemistry, 3rd Rank in University, Jiwaji University, Gwalior, M. P., India

  4. June 1988 - B. Sc. (Chemistry, Botany, and Zoology), First Rank in College, S. L. P. College, Jiwaji University, Gwalior, M. P., India
 
Research Experience:
  • Biochemistry, Protein Chemistry, Structure and function of proteins, Molecular Biology, Cell
  • Biology, Transcriptomics, and Metabolonomics
  • Drug Development, Drug designing, Drug resistance, Drug metabolism
Post Organization Period
Scientist 'C'

 Rajendra Memorial Research Institute of Medical Sciences (ICMR), Patna-800007, India 28.03.2008 To 01.06.2011.
Scientist 'D'

 Rajendra Memorial Research Institute of Medical Sciences (ICMR), Patna-800007, India 02.06.2011 To till date.
 
Membership/Fellowship:    
  • Indian Society of Parasitology
  • Society of Biological Chemists of India
  • The Japanese Society of Parasitology  
 
Awards: 
  1. Young Scientist Travel Bursary Award, The 9th Awaji International Forum on Infection & Immunity, JAPAN

  2. Post Doctoral Fellowship, Human Science Foundation (HSF) Tokyo, JAPAN from Jan.2004-March2005

  3. Post Doctoral Fellowship, Japan Society for the Promotion of Science (JSPS Fellow) Tokyo, JAPAN from Jan.2002- Jan 2004

  4. Post Doctoral Fellowship, National Science Council (NSC) Taiwan from March 1999-July 2001

  5. Research Associateship, Council of Scientific & Industrial Research (CSIR) New Delhi from 1997- Feb, 1999

  6. Senior Research Fellowship (CSIR) from 1994-1997

  7. Junior Research Fellowship, (CSIR) from 1992-1994

  8. GATE Card Holder: Qualified GATE Group (SEB) Feb. 1992, (96.07 Percentile)

  9. Qualified National Eligibility Test (NET) CSIR/UGC for Ph.D. Program and Lecturership in the field of Life Sciences, Dec. 1991

  10. 3rd Rank in merit list of University in M.Sc.
 
Foreign Visits:
  • 9Th Awaji International Forum on Infection & Immunity Conference and to visit Prof. Tomoyoshi Nozaki’s Lab. To JAPAN, From 2009-09-08 to 2009-09-19

  • The 45th Annual U.S-Japan. Joint Conference on Parasitic and Intestinal & Free-living Protozoan Parasites symposium, National Institute of Infectious Diseases, Tokyo, JAPAN. From 2011-01-10 to 2011-01- 15
 
Seminars/Symposiums/Workshops/Conference
  1. Vahab Ali, Vinod Bhakuni and Raja Roy (1993) Does Acid Phosphatase play any role in the growth of L. donovani promastigotes? Third Asian Congress of Parasitology, CDRI, PS-2.48, pp-115, Lucknow, India.

  2. Vinod Bhakuni and Vahab Ali (1993). Isolation and purification of lipophosphoglycan from non-pathogenic strain of L. donovani promastigotes.  Proceedings of IX carbohydrate conference, CDRI, OP-1, Lucknow, India.

  3. Vahab Ali and Vinod Bhakuni (1993). Lipophosphoglycan of L. donovani promastigote.  Proceeding of 62nd Annual Meeting of Society of Biological Chemists. MI-002, pp-113, Madurai, India.

  4. Vahab Ali (1994) Indo-German workshop on In vitro Toxicology. ITRC, Nov. 7-9, Lucknow, India.

  5. U.K. Singha, Vinod Bhakuni, Vahab Ali and Raja Roy (1995). Metabolite mapping of L. donovani promastigotes by proton nuclear magnetic resonance spectroscopy. XIIth National of Parasitology, Bio-1, pp-41, Panaji, Goa, India.

  6. U.K. Singha, Vahab Ali and Vinod Bhakuni (1995). Isolation and purification of secreted extracellular phosphoglycan of   L. donovani.  XIIth National Congress of Parasitology, Bio-II, pp-41, Panaji, Goa, India.

  7. Vahab Ali, U.K. Singha and Vinod Bhakuni (1995). Vaccination with lipophosphoglycan gives protection against visceral leishmaniasis. Proceedings of 64th Annual Meeting of Society of Biological Chemists, PlA29, pp-15, Lucknow, India.

  8. Raja Roy, P. K.  Mishra, Vahab Ali and Vinod Bhakuni (1995) Metabolite mapping in extracts of biological system by 1HNMR: Comparison of solvent suppression by various two dimensional NMR. First meeting of National Magnetic Resonance Society, 2-3 Feb, Bangalore, India.

  9. Vahab Ali, U.K. Singha and Vinod Bhakuni (1996) Enhanced efficacy of  lipophosphoglycan  mediated  protection  against  L.donovani infection  in  susceptible golden hamsters with  poly  IC:LC  Int. Congress of Parasitology, II-56, pp-124, 18-22 March, New Delhi, India

  10. Vahab Ali, U.K. Singha and Vinod Bhakuni (1996). In vitro and In vivo protection against L. donovani infection by lipophosphoglycan of non-pathogenic strain of L.  donovani.  Int.  Congress   of Parasitology, II-49, pp-119, 18-22 March, New Delhi, India.

  11. U.K. Singha, Vahab Ali, Vinod Bhakuni, H.B. Levy, and R.K.  Maheshwari (1996).  Immunochemotherapy for Leishmania donovani infection in golden hamsters:  Poly IC: LC plus stibanate. Int.  Congress of Parasitology, CDR-39, pp-205, 18-22 March, New Delhi, India.

  12. Vahab Ali, U.K. Singha and Vinod Bhakuni (1996). Efficacy of liposomised lipophosphoglycan of L. donovani promastigotes in providing protection against experimental visceral leishmaniasis. Society of Biological Chemists (India), J-14, pp-255, 20-23 Nov. Bangalore, India.

  13. U.K. Singha, Vahab Ali and Vinod Bhakuni (1996). Molecular characterization of   lipophosphoglycan of   L.  donovani promastigotes from pathogenic and non-pathogenic strains. Society of Biological Chemists (India). J-18, pp-257, 20-23 Nov. Bangalore, India.

  14. Vahab Ali, U.K.Singha & Vinod Bhakuni (1997). Immunoprophylactic/vaccine poten­tial of liposomised of lipophosphoglycan of Leishmania promastigote against experi­mental visceral leishmaniasis. Second Global Meet on Parasitic Diseases, pp. 256-257, 18-22, Aug., Hyderabad, India.

  15. U.K.Singha, S. Kulakarni, Vahab Ali, A.K. Rastogi & Vinod Bhakuni (1997). Efficacy of integral membrane proteins against L.donovani infection in susceptible golden hamsters. Second Global Meet on Parasitic Diseases, 18-22, Aug., Hyderabad, India, pp-255-256.

  16. Vahab Ali, Babu, K.R., Shashi Prajapati and Vinod Bhakuni (1998). Folding of acid unfolded cytochrome C by 8-anilino-1-naphthalene sulphonic acid (ANS). Twelfth Symposium of the Protein Society, 25-29 July, San Diego, California, U.S.A.

  17. Su-Chi Chiang, Vahab Ali, An-Li Huang, Kuan-Yu Chu and Sho Tone Lee (2000). Cloning, expression, cellular localization and functional characterization of a novel ICAM-like molecule of the immunoglobulin superfamily Leishmania parasites. Molecular Parasitology meeting XI, 246C, 17-21 Sep, Woods Hole, Massachusetts, U.S.A.

  18. Su-Chi Chiang, Vahab Ali, An-Li Huang, Kuan-Yu Chu and Sho Tone Lee (2001).  Molecular and functional characterization of an ICAM-like molecule in Leishmania parasites. Ninth Symposium on Recent Advances in Cellular and Molecular Biology, P-106, 3-5 Feb., Ken-ting, Taiwan (ROC).

  19. Vahab Ali, Su-Chi Chiang, and Sho Tone Lee (2001). ICAM-like molecule from Leishmania mexicana amazonensis binds to the CR3, and LFA-1 receptors of the macrophage. International conference of Leishmaniasis (Leish World II), P-79, 20-24 May, Crete, Greece.
  20. Nozaki Tomoyoshi, Vahab Ali, and Sanchez Lidya (2002). Molecular analysis of iron-sulfur cluster formation in parasitic protozoa. The II Awaji International Forum on Infection and Immunity, P-45, 24-27 Aug., Awaji Island, Hyogo, JAPAN.

  21. Nozaki Tomoyoshi, Vahab Ali, and Yasuhiro Takahashi (2003). Molecular analysis of iron-sulfur cluster formation in Entamoeba histolytica. The 72nd Annual Meeting of the Japanese Society of Parasitology & Centenary symposium to celebrate the Discovery of Schistosoma japonicum, 28-II-12, March 28-30, Kurume, JAPAN.

  22. Ali Vahab, Shigeta Yasuo and Nozaki Tomoyoshi (2003). Molecular and biochemical characterization of phosphoglycerate dehydrogenase and D-glycerate dehydrogenase of serine metabolic pathway from the enteric parasitic protist Entamoba histolytica. The III Awaji International Forum on Infection and Immunity, P-64, 25-28 Aug., Awaji Island, Hyogo, JAPAN.
  23. Nozaki Tomoyoshi, Ali Vahab, Tokumoto Umechiyo, Takahashi Yasuhiro (2003). Molecular and biochemical characterization of iron-sulfur cluster biosynthesis in the enteric parasitic protist Entamoeba histolytica. The III Awaji International Forum on Infection and Immunity, P-63, 25-28 Aug., Awaji Island, Hyogo, JAPAN.

  24. Tomoyoshi Nozaki, Vahab Ali, Umechiyo Tokumoto, Yasuhiro Takahashi and Barbara J Mann (2003). Molecular analysis of iron-sulfur cluster formation in the enteric parasitic protist Entamoeba histolytica. The 76th Annual Meeting of the Japanese Biochemical Society, 3P-471, 15-18 Oct. Yokohama, Tokyo, JAPAN. J. Biochem. (2003) 75, 979

  25. Vahab Ali, Yasuo Shigeta, Umechiyo Tokumoto, Yasuhiro Takahashi and Tomoyoshi Nozaki (2004). Iron-sulfur cluster assembly in the parasitic protist Entamoeba histolytica under anaerobic conditions. The 73th Annual Meeting of the Japanese Society of Parasitology, I-A-04, 3-4 Apr., Gumma, Maebashi, JAPAN.

  26. Tomoyoshi Nozaki, Vahab Ali, Kumiko Nakada-Tsukui, and Yasuhiro Takahashi (2004). Iron-sulfur cluster formation in the enteric protozoan Entamoeba histolytica: unique non-redundant nitrogen fixation (NIF)-like system in the anaerobic parasite. The IV Awaji International Forum on Infection and Immunity, P-081, pp. 117, 30 Aug.-02 Sept., Awaji Island, Hyogo, JAPAN.

  27. Tomoyoshi Nozaki, Vahab Ali, Kumiko Nakada-Tsukui, and Yasuhiro Takahashi (2004). Iron-sulfur cluster formation in the enteric protozoan Entamoeba histolytica: unique non-redundant nitrogen fixation (NIF)-like system in the anaerobic parasite. The IV Awaji International Forum on Infection and Immunity, III-3, pp. 59, 30 Aug.-02 Sept., Awaji Island, Hyogo, JAPAN.

  28. Vahab Ali and Tomoyoshi Nozaki (2004). Biochemical and functional characterization of phosphoserine aminotransferase involved in phosphorylated pathway of serine biosynthesis in the protozoan parasites Entamoeba histolytica. The IV Awaji International Forum on Infection and Immunity, P-076, pp. 114, 30 Aug.-02 Sept., Awaji Island, Hyogo, JAPAN.

  29. Vahab Ali, Kumiko Nakada-Tsukui, and Tomoyoshi Nozaki (2004). Role of the iron-sulfur cluster formation in the enteric protozoan Entamoeba histolytica: Functional characterization of non-redundant nitrogen fixation (NIF)-like system in the anaerobic parasite. Molecular Parasitology Meeting XV, 11C, 19-23 Sept., MBL Wood Holes, Massachusetts USA.

  30. Kumiko Nakada-Tsukui, Vahab Ali, Yumiko Saito-Nakano, and Tomoyoshi Nozaki (2004) Entamoeba histolytica Rab7A regulates the transport of a virulence factor cysteine protease via a specific interaction with the retromer-like complex. Molecular Parasitology Meeting XV, 249A, 19-23 Sept., MBL Wood Holes, Massachusetts USA.

  31. Vahab Ali and Tomoyoshi Nozaki (2004). Biochemical and functional analysis of serine metabolism in Entamoeba histolytica. The EMBO Workshop on: PATHOGENESIS OF AMOEBIASIS FROM GENOMICS TO DISEASE, P-029, pp. 79, 16-20 Nov., Kibbutz Ein Gedi, ISRAEL.

  32. Kumiko Nakada-Tsukui, Yumiko Saito-Nakano, Vahab Ali, and Tomoyoshi Nozaki (2005) The role of Rab7A in virulence of the enteric protozoan parasite Entamoeba histolytica. The 74th Annual Meeting of the Japanese Society of Parasitology, II-B-26, 8-9 Apr., Yonago, Totteri-ken, JAPAN.

  33. Vahab Ali, Kumiko Nakada-Tsukui, and Tomoyoshi Nozaki (2005). Roles of Fe-S cluster formations in anaerobic/microaerophilic metabolism of Entamoeba histolytica. KEYSTONE SYMPOSIA: Drugs against protozoan parasites (X6): Target selection, structural biology, and medicinal chemistry, 102, pp. 86, Apr. 9-13, Copper Mountain, Colorado, USA.

  34. Vahab Ali, Kumiko Nakada-Tsukui, and Tomoyoshi Nozaki (2005). Characterization of cytosolic Fe-S cluster assembly under anaerobic conditions in Entamoeba histolytica. International Conference on Anaerobic Protists, Oral presentation, PP-64, Sept. 17-20, Alghero, Italy.

  35. Vahab Ali, and Tomoyoshi Nozaki (2005). Toward understanding of cysteine biosynthesis pathway in parasitic protist Entamoeba histolytica. 4th Molecular Parasitology and Malaria Research Forum. Oral presentation, 17, pp. 23, Nov.5-6, Tokyo, Japan.

  36. Vahab Ali, Kumiko Nakada-Tsukui, and Tomoyoshi Nozaki (2006) Iron sulfur (Fe-S) cluster assembly in the enteric protozoan parasite Entamoeba histolytica: Localization, oxygen sensitivity, and physiological significance. 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, 1P-B-089, Page 165, 18-23 June, Kyoto, Japan.

  37. Vahab Ali and Tomoyoshi Nozaki (2006) Cysteine biosynthesis pathway in Entamoeba histolytica is a rational target to develop new chemotherapeutics against amebiasis. The 6th  Awaji International Forum on Infection and Immunity, P-040, pp. 82, 04-07 Sept., Awaji Island, Hyogo, Japan.

  38. Vahab Ali and Tomoyoshi Nozaki (2007) Regulation and physiological importance of sulphur-containing amino acid metabolism in Entamoeba histolytica. 41st Joint US-Japan Conference on Parasitic Diseases, pp. 20, 2-3 February, Tokyo, Japan.

  39. Sarwar Hussain, Vahab Ali, and Tomoyoshi Nozaki (2007) Characterizing and evaluating the role of serine O-acetyltransferase isoforms in cysteine biosynthetic pathway in E. histolytica. The 7th  Awaji International Forum on Infection and Immunity, P-149, 01-05 Sept., Awaji Island, Hyogo, Japan.

  40. Afzal Husain, Takako Hishiki, Carol A. Gilchrist, Vahab Ali, Makoto Suematsu, William A. Petri, Jr., and Tomoyoshi Nozaki (2007)Metabolomic and transcriptomic analysis of sulfur-containing amino acid metabolism in the enteric protozoan parasite Entamoeba histolytica. The 7th Awaji International Forum on Infection and Immunity, P-079, 01-05 Sept., Awaji Island, Hyogo, Japan.

  41. Vahab Ali, Afzal Husain, Tomoyoshi Nozaki (2007) Characterization of cysteine biosynthetic pathway: a potential drug target in Entamoeba histolytica. The 7th Awaji International Forum on Infection and Immunity, P-148, 01-05 Sept., Awaji Island, Hyogo, Japan.

  42. Ghulam Jeelani, S.B.A. Andrabi, Husain A., Vahab Ali, D. Sato, T.Soga, M. Suematsu and T. Nozaki, “Metabolomic approach to monitor metabolic flows in the Shikimate pathway of Plasmodium falciparum” 2008 in Global-COE Metabolomics symposium held at Keio University, Tokyo, Japan

  43. Andrabi, S.B.A., G. Jeelani, Husain A., Vahab Ali, D. Sato, T. Soga, M. Suematsu and T. Nozaki,“Exploring Ubiquinone biosynthesis pathway in Plasmodium falciparum using metabolomics approach” 2008 in Golabl-COE Metabolomics symposium held at Keio University, Tokyo, Japan

  44. Vahab Ali, Arti Kumari, Shadab Anwar, and Pradeep Das (2008). Toward understanding mechanism of multidrug resistance in visceral leishmaniasis.  20th National Congress of Parasitology, OP-15, pp-75, 3-5 November, Shillong, India.

  45. Vahab Ali (2008) Workshop on QRT-PCR: Two days hands on workshop on quantitative Real-Time-PCR organized by Genetix Biotech. Asia (P) Ltd. New Delhi, 25-26 Sept.2008, New Delhi, India.

  46. Vahab Ali, Arti Kumari, Shadab Anwar, Ashif Equbal, and Pradeep Das (2009) Biochemical and phenotypic characterization of unresponsive isolates of L. donovani and understand mechanism of multidrug resistance in visceral leishmaniasis. 4th World Congress on Leishmaniasis (WorldLeish4), #144, pp-161, 3-7 February, Lucknow, India.

  47. Vahab Ali, Krishn Pratap, Shadab Anwar, and Pradeep Das (2009) Biochemical and functional characterization of Iron Sulfur Clusters (ISC) machinery of L. donovani to understand the physiological role of Fe-S proteins in multidrug resistance parasites. The 9th Awaji International Forum on Infection and Immunity, P-075, pp-96, 08-11 Sept., Awaji Island, Hyogo, Japan.

  48. Ghulam Jeelani, Afzal Husain, Dan Sato, Makoto Suematsu, Vahab Ali, & Tomoyoshi Nozaki (2009) Biochemical and physiological function of a novel reductase from the microaerophilic protozoan parasite Entamoeba histolytica. The 9th Awaji International Forum on Infection and Immunity, P-070, pp-93, 08-11 Sept., Awaji Island, Hyogo, Japan
    .
  49. Afzal Husain, Ghulam Jeelani, Dan Sato, Fumika Mi-ichi, Tomoyoshi Soga, Makoto Suematsu, Vahab Ali, & Tomoyoshi Nozaki (2009) Metabolic and transcriptomic analysis of sulfur-containing amino acid metabolism in enteric protozoan parasite Entamoeba histolytica. The 9th Awaji International Forum on Infection and Immunity, P-071, pp-93, 08-11 Sept., Awaji Island, Hyogo, Japan.

  50. Vahab Ali (2009) Workshop on “Preparing/Writing manuscript for publication in Medical Journals” organised bu Medecins Sans Frontieres (MSF), 28 Oct. 2009, Patna, India.

  51. Vahab Ali, Krishn Pratap Singh, Amir Zaidi, and Pradeep Das (2011) Characterization of Iron Sulfur Clusters (ISC) machinery of L. donovani to understand the physiological role of Fe-S proteins in drug resistance. The 45th Annual Japan-U.S. Joint Conference on Parasitic, Invited speaker, pp-25, 10-11 Jan., National Institute of Infectious Diseases, Tokyo, Japan.

  52. Vahab Ali, Shadab Anwar, Suan E. Daniel, Pradeep Das and Tomoyoshi Nozaki (2011) Iron Sulfur Clusters (ISC) assembly of E. histolytica: Purification and characterization of cytosolic Fe-S clusters assembly components. The 45th Annual Japan-U.S. Joint Conference on Parasitic (Intestinal & Free-living Protozoan Parasites symposium), Invited speaker, pp-01, 12 Jan., National Institute of Infectious Diseases, Tokyo, Japan.

  53. Krishn Pratap Singh, Amir Zaidi, Pradeep Das, and Vahab Ali (2011) Interaction between IscS and IscU proteins of Fe-S cluster assembly machinery in Leishmania donovani.4th Bihar Science Conference, Oral, OP-BS-P-771, PP-44-55 11-13th February, Muzaffarpur, Bihar, India.

  54. Shadab Anwar, Susan E. Daniel, Pradeep Das, and Vahab Ali (2011) Expression, purification and characterization of cytosolic Fe-S clusters assembly components in enteric protozoan parasite E. histolytica. 4th Bihar Science Conference, Oral, OP-BS-P-774, PP-64-65, 11-13th February, Muzaffarpur, Bihar, India.

  55. Asif Equbal, Shashi S. Suman, Pradeep Das, and Vahab Ali (2011) Expression and purification of Trypanothione Synthetase of Leishmania donovani.4th Bihar Science Conference, Poster, PP-BS-P-775, PP-65, 11-13th February, Muzaffarpur, Bihar, India.

  56. Shashi S. Suman, Arti Kumari, Asif Equbal, Pradeep Das, and Vahab Ali (2011) Expression and purification of cytosolic tryparedoxin from Leishmania donovani. 4th Bihar Science Conference, Poster, PP-BS-P-776, PP-65, 11-13th February, Muzaffarpur, Bihar, India.
 
Major achievements:
  1. First time identified NIF system in E. histolytica is a single eukaryote possess this system for Fe-S clusters machinery.

  2. We have characterized and demonstrated function roles, cellular localization of Fe-S clusters assembly in amoeba first time.

  3. Biochemical and functional analysis of Sulfur containing amino acid metabolic pathways in E. histolytica and developed some anti-amoebic compounds.

  4. We have biochemically characterized iron sulfur clusters (ISC) assembly in Leishmania parasites first time.

  5. We have expressed & purified several proteins of L.donovani from thiol-metabolism lacks in human which may provide inside to develop chemotherapeutic against leishmaniasis.