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HOD (Molecular Biology)
Email: diroffice@icmr.org.in
Ph.: +91-612-2635456
Fax: +91-612-2634379

Dr. Pradeep Das, Director
 
A View of Molecular Lab.
Division of Molecular Biology

       Division of molecular biology is mainly concerned with the study on mechanism of pathogenesis, cell survival, cell death, differential gene expression, in–vitro and in-vivo rRNA processing, drug resistance mechanism, innate and cell mediated immunity and development of diagnostic tools for major protozoan parasite, L. donovani (blood parasite).
 
The Scientific Team
Name Qualification          Designation
Dr. Dharmendra Singh           Scientist C
 
The Students Team
Name Qualification          Designation
Ms. Sushmita Das M.Sc. (Zoology) Senior Research Fellow
Mr. Ashish Kumar M.Sc. (Biochemistry) Senior Research Fellow
Mr. Abul hasan Sardar M.Sc. (Microbiology) Senior Research Fellow
Mr. Bidyut Purkait     M.Sc. (Biotechnology) Junior Research Fellow
Mr. Manish Kumar M.Sc. (Biotechnology) Junior Research Fellow
 
Existing infrastructure: 

          Fluorescence Activated Cell Sorter- FACS (BD)
          DNA Sequencer (ABI)
          DNA Microarray (?)
          Real Time PCR (Roche)
          Gel-Doc (Bio-Rad)
          Electroporator (Bio-Rad)
          Thermal Cycler-PCR (ABI & MJ Research)
          2-D Gel Electrophoresis System (Bio-Rad))
          Pulse Field Gel Electrophoresis System (GE)
          Spectrofluorimeter (Perkin Elmer)
          Elispot / Immunospot analyzer (CTL)
          Fluorescence  (Olympus)
          Inverted Microscope (Nikon)
          FPLC (GE)
      
 
Majour Achievements :

        To construct the shotgun genomic DNA library of l.donovani.
        Identifying genes that are differentially expressed in amastigote compared to the                      promastigote classified into structural proteins, transporters, metabolism, amastins, heat            shock proteins and surface proteins.

        Identifying genes that are differentially expressed in Amphotericin B Drug resistant clinical            isolates compared to the Sensitive.
        Non invasive method for diagnosis of VL by rk-39 from sputum samples.
        TGF-β-regulated tyrosine phosphates induce lymphocyte apoptosis in Leishmania            donovani-infected hamsters.
        Hydrogen Peroxide Induces Apoptosis like Death in Entamoeba histolytica Trophozoites.