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HOD (Immunology)
Email: sbimal@yahoo.com
Ph.: +91-612-2635456
Fax: +91-612-2634379

Dr. Sanjiva Bimal
 
A View of Immunology Lab
The Division of Immunology is actively participating in mainstream research programmes of the Institute. Our principle focuses of research are immunodiagnosis, mechanism of Immunosuppressions and Immunoprophylactic aspects of visceral leishmaniasis. Besides, the Division offers 'on the job training courses' to post graduate students from various Universities in India. To accomplish the above, the division has fully developed infrastructure.
The Scientific Team
Name Qualification          Designation
Dr. Sanjiva Bimal
M.Sc., Ph.D.
Scientist E
 
The Students Team
Name Qualification          Designation
Mr. Rajesh Chaudhary
M.Sc. (Biochemistry)
Sr. Research Fellow
Mr. Anupam Yadav
M.Sc. (Biotechnology)
Ph.D. Scholar
Mr. Ajay Amit M.Sc. (Biotechnology) Jr. Research Fellow
Mr. Vijay Mahantesh M.Sc. (Biotechnology) Ph.D. Scholar
 
Existing infrastructure:
  • Well Equipped Animal Cell Culture facility
  • Flow Cytometry (FACS Calibur, 4-colour)
  • High Yield Florescent Microscope
  • ELISA Reader
  • Well equipped parasite culture, propagation and cryopreservation facility.
  • Refrigerated micro and Plate Centrifuge
  • Proteomics Lab.
  • Lyophilizer
  • Vertical Gel Electrophoresis
  • Western blotting system
  • Gel Documentation system
  • Facilities for molecular studies
  • Thermal Cycler (PCR)
  • Horizontal Gel Electrophoresis
  • High Speed Cold Centrifuge (50,000xg)
  • Cold chain for storage of reagents.
  • All other basic equipments required for immunological research

Research Activity:

Ongoing Research Projects:

  • Study of Leishmania proteins for their role in immunity and protection in visceral leishmaniasis.
  • Evaluation of immunodiagnostics and study for new diagnostics for VL.
  • Studies on innate immune function in VL.
  • Study of regulatory function in VL.
Other Scientific & Academic assignments:

Diagnostic:

  • Serological Diagnostics of kala-azar
  • Evaluation of CD4 status in HIV subjects before and during ART.

Training:

  • Training and guidance for project dissertation to the students of M.Sc. and M.Tech. students of different Universities.

Teaching:

  • To the Ph.D. students during course work and to the project trainees.

Guidance of research scholars:

  • Imparting training & guidance to the student working as SRF, JRF and research fellow for Ph.D.
  • Project Guidance to M. Pharm. student from NIPER, Hajipur.
 
Major Achievements : 
  • Reported a preferential defect in expression of HLA-DR antigen on monocytes in Indian Kala-Azar patients (1992).Further studies identified HLA-DQ11 as a susceptible factor in KA patients ( 1996).
  • Evaluated and established Direct Agglutination Test (DAT) as a diagnostic tool for detection of sub-clinical infection of Kala-azar.
  • Evaluation of field suitability of rapid diagnostics.
  • Establishing for the first time in Kala-azar a role of CD2 in protective immunity, testing the feasibility of use of CD2 in a new immune-chemotherapeutical approach for Kala-azar control
  • Reported for the first time that the pattern of immunity in T-cells infected with Leishmania of one strain may alter when the same T-cell is sensitized with other strain differing in response magnitude.
  • Among many projects supported by us, the reports made on role of ABC transporters in drug resistance and immunological features in HIV-VL co-infection are very useful for future research.
  • An immuno-chemotherapeutical approach by using CD2 as IFN-gamma promoter for SAG drug for control of Kala-azar was attempted and is likely to contribute significantly as translational product in future.
  • A new whole Blood Assay system for evaluating the innate immune function in VL patients and under malnutrition is being studied in Indo-German Project.
  • A collaborative work by RMRI (India), BHU (India) and Belgium, on field applicability of novel diagnostic tests was carried out funded by WHO/TDR which proved a high sensitivity and specificity of rK-39 for diagnosis of Kala-azar in field
  • Identified and reported many plants with anti-leishmanial efficacy.