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Annual Reports
RMRIMS News Bulletine
 


 

OVERVIEW
Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna was established in the memory of the First President of Republic of India Deshratna Dr. Rajendra Prasad in the year 1963 with Asthma as its mandate. It was taken over by Indian Council of Medical Research, New Delhi on 1st April, 1984 under Ministry of Health and Family Welfare, Govt. of India and thereafter the main thrust area is Visceral Leishmaniasis (Kala-azar).

EXISTING FACILITIES
This Institute has well equipped departments viz. Clinical medicine with OPD and 50-bedded Indoor facility, Pathology, Biochemistry, Microbiology, Immunology, Molecular biology, Epidemiology, Animal house, Social science, Biostatistics, Bioinformatics and Library. Some of the modern equipment are: Fully automated clinical chemistry analyzer, semi-auto analyzer, Flow cytometer, PCR, Gel-documentation system, Microarray, DNA sequencer, RT-PCR, 2D gel electrophoresis system, HPLC, FPLC, Cell–counter, Ion-selective analyzer etc besides the other routine instruments for the research purpose.
Our modern library and information system is featured with online bibliographic access through various online database search tools like ProQuest, ERMSS, J-Gate, JCCC etc. We also have guest house as well as International hostel to provide accommodation to our guests and scholars.  


COLLABORATION
The institute is well recognized by the national and International agencies viz. World Health Organization (WHO/TDR), Institute for OneWorld Health, GlaxoSmithKline, DNDi, MSF, Bharat Serum and Vaccine Ltd. for clinical drug trials. We have collaborated with Department of Biotechnology, European Commission, WHO/TDR etc. for advance basic and epidemiological research. The institute has been identified by WHO as reference centre for Leishmania parasite and Sera Bank; and we serve as one of the WHO centers for RDT evaluation networking.


EXTENDED FACILITIES
A tropical disease research centre cum hospital with a 150-bedded indoor facility is coming up in the Institute premises along with all the latest diagnostic and management facilities. Other facilities include ICTC for HIV counseling and testing, ART centre for AIDS treatment, Virology lab with H1N1 testing facility and IRL Tuberculosis laboratory for diagnosis, management and research purpose. We are the mentor institute for National Institute of Pharmaceutical Education and Research (NIPER), Hajipur.


OBJECIVES
The broad objective of the Institute is to undertake research on clinical, basic and applied aspects of kala-azar.

 

Major Achievements
Successful application of PCR as better diagnostic test for Kala-azar as compared to conventional microscopy of bone marrow/ splenic aspirate, and similarly also in PKDL cases, especially with macular lesion, where sensitivity of conventional microscopy of slit kin/ biopsy is very poor is a remarkable achievement. The Institute has undertaken various clinical drug trials for VL and PKDL to assess safety and efficacy of new molecules as well as combination therapies of the existing drugs, out of which miltefosine, the first ever oral drug, have been introduced in Kala-azar elimination programme and paromomycin has been registered by Govt. of India. Apart from the other clinical trials, dose-finding study of miltefosine for treatment of PKDL cases is of great importance.
It has been experimentally demonstrated that plants’ extract may be used as replacement of costly animal products for in-vitro propagation of Leishmania promastigotes and some the plants that exhibit lethal effort may be further explored for its potentiality as anti-VL drug in future. Twenty two different isolates of Leishmania and 119 sera samples of various categories of Kala Azar patients have been archived in the Leishmaina repository and sera bank.
A genomic DNA microarray library from Indian strain has been constructed to study differential gene expression related to development and regulatory pathogenicity in the different developmental stages and drug resistant and susceptible strains of L. donovani.
Through operational research, tremendous work has been done for effective vector management for VL elimination. In collaboration with WHO/TDR, monitoring and evaluation toolkit for IRS has been developed and training was imparted for its implementation at the ground level. Software using remote sense and GIS developed in collaboration with RRSC, Kharagpur for predicting vector density and endemicity.


Human Resource Development:
HRD includes training to P.G. students of Life Sciences; training to M.O.s, DMOs, KTS, VBD Consultants etc. involved in Kala-azar elimination programme. We are affiliated with T.M. Bhagalpur University and Calcutta University for Ph.D. degree programme.